School of Medicine - Basic Medical ScienceImmunology

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2019.4.9

Our research is focused on the regulation mechanisms of various immune responses. In the past years, we have characterized several proteins that are involved in cytokine trafficking and the regulation of serine protease activity using mouse models.

Specific areas of interest include:
The origin, development, and function of mononuclear phagocytes (dendritic cells, monocytes, and macrophages).
The regulation of cytokine production from innate immune cells.

Contact Information

TEL: 076-218-8121 / FAX: 076-218-8121 / Email: serol@kanazawa-med.ac.jp

Faculty

Professor and Chair

  • ONAI Nobuyuki

Senior Assistant Professor

  • YABE-WADA Toshiki

Assistant Professor

  • MATSUBA Shintaro
  • SAITO Fumiji

Research Achievements

Research Activities

  • Yabe-Wada T, Matsuba S, Takeda K, Sato T, Suyama M, Ohkawa Y, Takai T, Shi H, Philpott CC,
    Nakamura A
    TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin
    Sci. Rep. 6, 26566; doi: 10.1038/srep26566 (2016)
  • Guilliams M*, Ginhoux F*, Jakubzick C*, Naik SH*, Onai N*, Schraml BU*, Segura E, *Tussiwand R*,
    Yona, S*
    Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny.
    Nat. Rev. Immunol. 14: 571-578 (2014)
  • Ohyagi H#, Onai N#, Sato T, Yotsumoto Y, Liu J, Akiba H, Yagita H, Atarashi K, Honda K, Roers A, Müller W, Kurabayashi K, Hosoi-Amaike M, Takahashi N, Hirokawa M, Matsushima K, Sawada K, *Ohteki T
    Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses.
    Immunity 39: 584-598 (2013) (#These authors contributed equally to this work)
  • Onai N, Kurabayashi K, Hosoi-Amaike M, Toyama-Sorimachi N, Matsushima K, Inaba K, Ohteki T.
    A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential.
    Immunity 2013 42: 943-957(2013)
  • Onai N, Obata-Onai A, Schmid MA, Ohteki T, Jarrossay D, Manz MG
    Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow.
    Nat. Immunol. 8: 1207-1216(2007)